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Mitochondria-derived 16-amino acid peptide encoded in the mt-genome, studied for AMPK activation, insulin sensitivity, and metabolic homeostasis regulation.
Description
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-c) is a mitochondria-derived peptide encoded in the mitochondrial genome. It is a 16-amino acid peptide that acts as a retrograde signal from the mitochondria to the nucleus, regulating nuclear gene expression and metabolic homeostasis.
Research has shown MOTS-c to regulate skeletal muscle metabolism, improve insulin sensitivity, and protect against age-dependent and diet-induced obesity. It activates AMPK and has been found to accumulate in the nucleus in response to metabolic stress. Studies suggest it may represent a key link between mitochondrial function, aging, and metabolic health. This compound is for research purposes only.
Frequently Asked Questions
What is MOTS-c?
MOTS-c is a mitochondria-derived peptide encoded within the 12S rRNA gene. It is studied for its role in metabolic homeostasis, exercise mimetic effects, and potential anti-aging applications through AMPK pathway activation.
How does MOTS-c relate to longevity research?
MOTS-c activates AMPK signaling, a key metabolic sensor involved in cellular energy homeostasis. Research suggests it may improve insulin sensitivity, enhance exercise capacity, and protect against age-related metabolic decline.
What purity is VeloxPeptide's MOTS-c?
Our MOTS-c is HPLC-verified with 99%+ purity and includes a certificate of analysis (CoA) confirming identity and purity for reliable research applications.
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